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Publications of Pfanner Lab

2020

  • Rampelt H, Sucec I, Bersch B, Horten P, Perschil I, Martinou JC, van der Laan M, Wiedemann N, Schanda P, Pfanner N: The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments. BMC Biol, 2020; 18: 2.
  • Doan KN, Grevel A, Martensson CU, Ellenrieder L, Thornton N, Wenz LS, Opalinski L, Guiard B, Pfanner N, Becker T: The mitochondrial import complex MIM functions as main translocase for α-helical outer membrane proteins. Cell Rep, 2020; 31: 107567.
  • Grevel A, Pfanner N, Becker T: Coupling of import and assembly pathways in mitochondrial protein biogenesis. Biol Chem, 2020; 401: 117-129.
  • Priesnitz C, Pfanner N, Becker T: Studying protein import into mitochondria. Methods Cell Biol, 2020; 155: 45-79.
  • Colina-Tenorio L, Horten P, Pfanner N, Rampelt H: Shaping the mitochondrial inner membrane in health and disease. J Intern Med, 2020; 287: 645-664.

2019

  • Ellenrieder L, Dieterle MP, Doan KN, Martensson CU, Floerchinger A, Campo ML, Pfanner N, Becker T: Dual role of mitochondrial porin in metabolite transport across the outer membrane and protein transfer to the inner membrane. Mol Cell, 2019; 73: 1056-1065.
  • Pfanner N, Warscheid B, Wiedemann N: Mitochondrial proteins: from biogenesis to functional networks. Nat Rev Mol Cell Biol, 2019; 20: 267-284.
  • Becker T, Song J, Pfanner N: Versatility of preprotein transfer from the cytosol to mitochondria. Trends Cell Biol, 2019; 29: 534-548.
  • Pfanner N, Zimmermann R, Hartl FU: Walter Neupert (1939–2019). Cell, 2019; 178: 1031-1033.  Reprinted in Mol. Cell, 2019; 75: 661-663.
  • Araiso Y, Tsutsumi A, Qiu J, Imai K, Shiota T, Song J, Lindau C, Wenz LS, Sakaue H, Yunoki K, Kawano S, Suzuki J, Wischnewski M, Schütze C, Ariyama H, Ando T, Becker T, Lithgow T, Wiedemann N, Pfanner N, Kikkawa M, Endo, T: Structure of the mitochondrial import gate reveals distinct preprotein paths. Nature, 2019; 575: 395-401.

2018

  • Höhr AIC, Lindau C, Wirth C, Qiu J, Stroud DA, Kutik S, Guiard B, Hunte C, Becker T, Pfanner N, Wiedemann N: Membrane protein insertion through a mitochondrial β-barrel gate. Science, 2018; 359: eaah6834.
  • Song J, Pfanner N, Becker T: Assembling the mitochondrial ATP synthase. Proc Natl Acad Sci USA, 2018; 115: 2850-2852.
  • Rampelt H, Wollweber F, Gerke C, de Boer R, van der Klei IJ, Bohnert M, Pfanner N, van der Laan M: Assembly of the mitochondrial cristae organizer Mic10 is regulated by Mic26-Mic27 antagonism and cardiolipin. J. Mol. Biol., 2018; 430: 1883-1890.
  • Opalinski L, Song J, Priesnitz C, Wenz LS, Oeljeklaus S, Warscheid B, Pfanner N, Becker T: Recruitment of cytosolic J-proteins by TOM receptors promotes mitochondrial protein biogenesis. Cell Rep, 2018; 25: 2036-2043.

2017

  • Krüger V, Becker T, Becker L, Montilla-Martinez M, Ellenrieder L, Vögtle FN, Meyer HE, Ryan MT, Wiedemann N, Warscheid B, Pfanner N, Wagner R, Meisinger C: Identification of new channels by systematic analysis of the mitochondrial outer membrane. J Cell Biol, 2017; 216: 3485-3495.
  • Wiedemann N, Pfanner N: Mitochondrial machineries for protein import and assembly. Annu Rev Biochem, 2017; 86: 685-714; epub March 15, 2017.
  • Hessenberger M, Zerbes RM, Rampelt H, Kunz S, Xavier AH, Purfürst B, Lilie H, Pfanner N, van der Laan M, Daumke O: Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions. Nat Commun, 2017; 8: 15258.
  • Rampelt H, Bohnert M, Zerbes RM, Horvath SE, Warscheid B, Pfanner N, van der Laan, M: Mic10, a core subunit of the mitochondrial contact site and cristae organizing system, interacts with the dimeric F1Fo-ATP synthase. J Mol Biol, 2017; 429: 1162-1170.
  • Rampelt H, Zerbes RM, van der Laan M, Pfanner N: Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics. Biochim Biophys Acta, 2017; 1864: 737-746.
  • Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmaier S, Drepper F, Weill U, Höß P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schütze C, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B: Definition of a high-confidence mitochondrial proteome at quantitative scale. Cell Rep, 2017; 19: 2836-2852
     

Selected Previous Publications

  • Chatterjee A, Syefferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Martensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A: MOF acetyl transferase regulates transcription and respiration in mitochondria. Cell, 2016; 167: 722-738.
  • Rampelt H, Pfanner N: Coordination of two genomes by mitochondrial translational plasticity. Cell, 2016; 167: 308-310.
  • Shiota T, Imai K, Qiu J, Hewitt VL, Tan K, Shen HH, Sakiyama N, Fukasawa Y, Hayat S, Kamiya M, Elofsson A, Tomii K, Horton P, Wiedemann N, Pfanner N, Lithgow T, Endo T: Molecular architecture of the active mitochondrial protein gate. Science, 2015; 349, 1544-1548.
  • Harbauer AB, Opalinska M, Gerbeth C, Herman JS, Rao S, Schönfisch B, Guiard B, Schmidt O, Pfanner N, Meisinger C: Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science, 2014; 346: 1109-1113.
  • Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T: Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell, 2013; 154 (3) : 596-608: http://dx.doi.org/10.1016/j.cell.2013.06.033
  • Schmidt O, Harbauer AB, Rao S, Eyrich B, Zahedi RP, Stojanovski D, Schonfisch B, Guiard B, Sickmann A, Pfanner N, Meisinger C: Regulation of mitochondrial protein import by cytosolic kinases. Cell, 2011; 144 (2) : 227-239: http://dx.doi.org/10.1016/j.cell.2010.12.015
  • Stroud DA, Meisinger C, Pfanner N, Wiedemann N: Biochemistry. Assembling the outer membrane. Science, 2010; 328 (5980) : 831-832: http://dx.doi.org/10.1126/science.1190507
  • Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N: Importing mitochondrial proteins: machineries and mechanisms. Cell, 2009; 138 (4) : 628-644: http://dx.doi.org/10.1016/j.cell.2009.08.005
  • Wiedemann N, Meisinger C, Pfanner N: Cell biology. Connecting organelles. Science, 2009; 325 (5939) : 403-404: http://dx.doi.org/10.1126/science.1178016
  • Wiedemann N, van der Laan M, Pfanner N: SnapShot: import and sorting of mitochondrial proteins. Cell, 2009; 138 (4) : 808-808.e1: http://dx.doi.org/10.1016/j.cell.2009.08.004
  • Vögtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C: Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell, 2009; 139: 428-439.
  • Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke, M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N., and Wiedemann, N. (2008). Dissecting membrane insertion of mitochondrial β-barrel proteins. Cell 132, 1011-1024.
  • Meisinger, C., Sickmann, A., and Pfanner, N. (2008). The mitochondrial proteome: from inventory to function. Cell 134, 22-24.
  • Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick, D.U., Hutu, D.P., Voos, W., Truscott, K.N., Chacinska, A., Pfanner, N., and Rehling, P. (2006). Tim50 maintains the permeability barrier of the mitochondrial inner membrane. Science 312, 1523-1526.

  • Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. (2005). Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829.

  • Pfanner, N., Wiedemann, N., and Meisinger, C. (2004). Double membrane fusion. Science 305, 1723-1724.

  • Rehling, P., Model, K., Brandner, K., Kovermann, P., Sickmann, A., Meyer, H.E., Kühlbrandt, W., Wagner, R., Truscott, K.N., and Pfanner, N. (2003). Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299, 1747-1751.

  • Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., and Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571.

  • Geissler, A., Chacinska, A., Truscott, K.N., Wiedemann, N., Brandner, K., Sickmann, A., Meyer, H.E., Meisinger, C., Pfanner, N., and Rehling, P. (2002). The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell 111, 507-518.

  • van Wilpe, S., Ryan, M.T., Hill, K., Maarse, A.C., Meisinger, C., Brix, J., Dekker, P.J.T., Moczko, M., Wagner, R., Meijer, M., Guiard, B., Hönlinger, A., and Pfanner, N. (1999). Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature 401, 485-489.

  • Voisine, C., Craig, E.A., Zufall, N., von Ahsen, O., Pfanner, N., and Voos, W. (1999). The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70. Cell 97, 565-574.

  • Hill, K., Model, K., Ryan, M.T., Dietmeier, K., Martin, F., Wagner, R., and Pfanner, N. (1998). Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins. Nature 395, 516-521.

  • Dietmeier, K., Hönlinger, A., Bömer, U., Dekker, P.J.T., Eckerskorn, C., Lottspeich, F., Kübrich, M., and Pfanner, N. (1997). Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature 388, 195-200.

  • Kiebler, M., Keil, P., Schneider, H., van der Klei, I.J., Pfanner, N., and Neupert, W. (1993). The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell 74, 483-492.

  • Pfanner, N., Rassow, J., van der Klei, I.J., and Neupert, W. (1992). A dynamic model of the mitochondrial protein import machinery. Cell 68, 999-1002.

  • Söllner, T., Rassow, J., Wiedmann, M., Schloßmann, J., Keil, P., Neupert, W., and Pfanner, N. (1992). Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature 355, 84-87.

  • Schneider, H., Söllner, T., Dietmeier, K., Eckerskorn, C., Lottspeich, F., Trülzsch, B., Neupert, W., and Pfanner, N. (1991). Targeting of the master receptor MOM19 to mitochondria. Science 254, 1659-1662.

  • Söllner, T., Pfaller, R., Griffiths, G., Pfanner, N., and Neupert, W. (1990). A mitochondrial import receptor for the ADP/ATP carrier. Cell 62, 107-115.

  • Kiebler, M., Pfaller, R., Söllner, T., Griffiths, G., Horstmann, H., Pfanner, N., and Neupert, W. (1990). Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature 348, 610-616.

  • Neupert, W., Hartl, F.-U., Craig, E.A., and Pfanner, N. (1990). How do polypeptides cross the mitochondrial membranes? Cell 63, 447-450.

  • Kang, P.-J., Ostermann, J., Shilling, J., Neupert, W., Craig, E.A., and Pfanner, N. (1990). Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature 348, 137-143.

  • Söllner, T., Griffiths, G., Pfaller, R., Pfanner, N., and Neupert, W. (1989). MOM19, an import receptor for mitochondrial precursor proteins. Cell 59, 1061-1070.

  • Pfanner, N., Orci, L., Glick, B.S., Amherdt, M., Arden, S.R., Malhotra, V., and Rothman, J.E. (1989). Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae. Cell 59, 95-102.

  • Pfanner, N., Tropschug, M., and Neupert, W. (1987). Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell  49, 815-823.