You are here: Home News from the Institute … Tom22, the Bouncer of the …

Tom22, the Bouncer of the Mitochondrion

Tom22, the Bouncer of the Mitochondrion

© Rissler

Freiburg researcher discovers three signalling pathways that
regulate the gates to the powerhouses of the cell

Mitochondria burn sugar and supply the cell with energy. They were long
thought to be structures that are relatively independent of the cell. However,
Carolin Gerbeth, a PhD student from the trinational research training group
“Membrane Proteins and Biological Membranes,” has now identified no less
than three signalling paths the cell uses to influence processes in the
mitochondrion. In baker’s yeast, she and her colleagues at the University of
Freiburg found three enzymes that regulate the transport of proteins into the
mitochondria. The team published its findings in the journal “Cell
Metabolism”. “Our work lays an important foundation for investigating
signalling pathways like these in humans and determining what role they
play in the development of illnesses. In tumour cells the mitochondrial
energy metabolism is dysregulated, and it is possible that this
reprogramming is conveyed over these newly discovered signalling paths,”
explains project head Prof. Dr. Chris Meisinger, Cluster of Excellence
BIOSS Centre for Biological Signalling Studies and Institute of Biochemistry
and Molecular Biology of the University of Freiburg.  » more