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 Bibliography       PubMed







  • Cabrera-Orefice, A., Yoga, E.G., Wirth, C., Siegmund, K., Zwicker, K., Guerrero-Castillo, S., Zickermann, V., Hunte, C., and Brandt, U. (2018). Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nature communications 9, 4500.
  • Argy N, Le Gal S, Coppée R, Song Z, Vindrios W, Massias L, Kao WC, Hunte C, Yazdanpanah Y, Lucet JC, Houzé S, Clain J, Nevez G (2018) Pneumocystis cytochrome b mutants associated with atovaquone prophylaxis failure as the cause of Pneumocystis infection outbreak among heart transplant recipients, Clin. J. Infect. Dis., Mar 3. doi: 10.1093/cid/ciy154. [Epub ahead of print]
  • Eimer E, Kao WC, Fröbel J, Blümmel AS, Hunte C and Müller M (2018) Unanticipated functional diversity among the TatA-type components of the Tat protein translocase, Sci. Rep. 8, 1326 
  • Höhr AIC, Lindau C, Wirth C, Qiu J, Stroud DA, Kutik S, Guiard B, Hunte C, Becker T, Pfanner N, Wiedemann N (2018) Membrane protein insertion through a mitochondrial β-barrel gate, Science 359 (6373), pii: eaah6834. doi: 10.1126/science.aah6834
  • Fuchs, S., Hansen, S.C., Markones, M., Mymrikov, E.V., Heerklotz, H., and Hunte, C. (2018). Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1. Sci Rep 8, 14837.



  • Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K (2017) Protein glutaminylation is a yeast-specific post-translational modification of elongation factor 1A, J. Biol. Chem. 292, 16014-16023
  • Meisinger C, Hunte C (2017) Recent Advances in Mitochondrial Biology – Integrated Aspects. Cell & Tiss. Res. 367, 1-3.



  • Graf S, Fedotovskaya O, Kao WC, Hunte C, Ädelroth P, Bott M, von Ballmoos C, Brzezinski P (2016) Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum. Science Rep. 6: 34098, doi: 10.1038/srep34098
  • Kao W, Kleinschroth T, Nitschke W, Baymann F, Neehaul Y, Hellwig P, Richers S, Vonck J, Bott M, Hunte C (2016) The actinobacterial obligate respiratory supercomplex from Corynebacterium glutamicum. Biochim. Biophys. Acta 1857, 1705-1714
  • Wirth C, Brandt U, Hunte C, Zickermann V (2016) Structure and function of mitochondrial complex I, Biochim. Biophys. Acta, 1857, 902-914.
  • Müller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte U (2016) Cryo-slicing BN-MS – a novel technology for high-resolution complexome profiling, Mol. Cell. Proteom. 15, 669-681.



  • Kmita K, Wirth C, Warnau J, Guerrero-Castillo S Hunte C, Hummer G, Kaila VRI, Zwicker K, Brandt U, Zickermann V (2015) Accessory NUMM (NDUFS6) subunit harbors a zinc-binding site and is essential for biogenesis of mitochondrial complex I, Proc. Natl. Acad. Sci. USA  112, 5685-5690
  • Mir SH, Escher C, Kao WC, Birth D, Wirth C, Hunte C (2015) Generation of recombinant antibody fragments for membrane protein crystallization. Methods Enzym. 557, 201-218
  • Zickermann V, Christophe Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Ulrich Brandt U (2015) Mechanistic Insight from the Crystal Structure of Mitochondrial Complex, Science 347, 44-49
  • Chauvet AA, Al Haddad A, Kao WC, van Mourik F, Hunte C, Chergui M (2015) Photo-induced dynamics of the heme centers in the cytochrome bc1. Phys. Chem. Chem. Phys. 17 (3), 2143-2151



  • Kao WC, Hunte C (2014) The molecular evolution of the Qo motif. Genome Biol.  Evol. 6, 1894-1910
  • Călinescu O, Danner E, Böhm M, Hunte C and Fendler K (2014) Species differences in bacterial NhaA Na+/H+ exchangers, FEBS Lettr. 588, 3111-3116
  • Lentes CJ, Mir SM, Boehm M, Ganea C, Fendler K, Hunte C (2014) Molecular characterization of the Na+/H+ antiporter NhaA from Salmonella Typhimurium. PLOS ONE 9(7):e101575; doi: 10.1371/journal.pone.0101575
  • Birth D, Kao WC, Hunte C (2014) Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat. Comm. 5, 4029; doi: 10.1038/ncomms5029.



  • Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T: Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell, 2013; 154 (3) : 596-608:
  • Jank T, Bogdanovic X, Wirth C, Haaf E, Spoerner M, Böhmer KE, Orth JHC, Kalbitzer HR, Warscheid B, Hunte C, Aktories K (2013) Tyrosine Glycosylation of Rho by a Photorhabdus asymbiotica Toxin. Nat. Struct. Mol. Biol. 2013 Oct 20. doi: 10.1038/nsmb.2688. [Epub ahead of print]



  • Bottinger L, Horvath SE, Kleinschroth T, Hunte C, Daum G, Pfanner N, Becker T: Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes. J Mol Biol, 2012; 423 (5) : 677-686:
  • Gebert M, Schrempp SG, Mehnert CS, Heisswolf AK, Oeljeklaus S, Ieva R, Bohnert M, von der Malsburg K, Wiese S, Kleinschroth T, Hunte C, Meyer HE, Haferkamp I, Guiard B, Warscheid B, Pfanner N, van der Laan M: Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J Cell Biol, 2012; 197 (5) : 595-604:



  • Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N: Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell, 2011; 44 (5) : 811-818:
  • Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dotsch V, Hunte C, Sitte HH, Koepsell H: The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. J Biol Chem, 2011; 286 (43) : 37874-37886:
  • Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C: X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-A resolution. Bba-bioenergetics, 2011; 1807 (12) : 1606-1615:
  • Stroud DA, Becker T, Qiu J, Stojanovski D, Pfannschmidt S, Wirth C, Hunte C, Guiard B, Meisinger C, Pfanner N, Wiedemann N: Biogenesis of mitochondrial beta-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol Biol Cell, 2011; 22 (16) : 2823-2833:
  • Zickermann V, Hunte C, Brandt U: Mitochondrialer Komplex I – Analyse einer molekularen Maschine. Biospektrum, 2011; 17: 278-280
  • Ma L, Reisert M, Wirth C, Hunte C, Ronneberger O, Burkhardt H: Alpha helix prediction based on Metropolis-Hastings sampling. Biomedical Imaging: From Nano to Macro. In: IEEE International Symposium IEEE, 2011



  • Hunte C, Zickermann V und Brandt U. (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. Science 329, 448-451, published online 1 July 2010

  • Kongkathip N, Pradidphol N, Hasitapan K, Grigg R, Kao WC, Hunte C, Fisher N, Warman AJ, Biagini GA, Kongsaeree P, Chuawong P, Kongkathip B. (2010) Transforming Rhinacanthin Analogues from Potent Anticancer Agents into Potent Antimalarial Agents. J Med Chem. 53, 1211-1221

  • Dobrynin K, Abdrakhmanova A, Richers S, Hunte C, Kerscher S, Brandt U (2010)Characterization of two different acyl carrier proteins in complex I from Yarrowia lipolytica. Biochim. Biophys. Acta 1797, 152-159

  • MacMillan F, Lange C, Bawn M, Hunte C (2010) Resolving the EPR spectra in the Cytochrome bc1 Complex from Saccharomyces cerevisiae. Applied Magnetic Resonance 37, 305-316

  • Zickermann V, Wumaier Z, Wrzesniewska B, Hunte C, Schägger H (2010) A native blot system for detection and characterization of conformation-specific antibodies, Proteomics 10, 159-63


Previous Publications

  • Boesecke P, Bois JM, Crépin T, Hunte C, Kahn R, Kao WC, Nauton L, Lund Winther AM, Moller J, Nissen P, Nury H, Olesen C, Pebay-Peyroula E, Vicat J, Stuhrmann H (2009) A first low resolution difference fourier map of phosphorus in a membrane protein from near edge anomalous diffraction. J. Synchr. Radiation 16, 658-665
  • Wenz T, Hielscher R, Hellwig P, Schägger H, Richers S, Hunte, C (2009) Role of phospholipids in respiratory cytochrome bc1 complex catalysis and supercomplex formation. Biochim. Biophys. Acta, 1787, 609-616
  • Hielscher R, Wenz T, Hunte, C, Hellwig P (2009) Monitoring the redox and protonation dependent contributions of cardiolipin in electrochemically induced FTIR difference spectra of the cytochrome bc1 complex from yeast. Biochim. Biophys. Acta 1787, 617–625
  • Džafić E, Klein O, Screpanti E, Hunte C, Mäntele W (2009) Flexibility and dynamics of NhaA Na(+)/H(+)-antiporter of Escherichia coli studied by Fourier transform infrared spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 72, 102-109


  • Hunte C, Richers S (2008) Lipids and membrane protein structures. Curr. Op. Struct. Biol. 18, 406-411 (review)
  • Nyola, A., Hunte C. (2008) A structural analysis of the transient interaction between cytochrome bc1 complex and its substrate cytochrome c. Biochem. Soc. Trans. 36, 981-985 (review)
  • Solmaz SR and Hunte C (2008) Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. J Biol. Chem. 283, 17542-17549
  • Keller T, Schwarz D, Bernhard F, Dötsch V, Hunte C, Gorboulev V, Koepsell H. (2008) Cell Free-Expression and Functional Reconstitution of Eucaryotic Drug Transporters. Biochem. 47, 4552-4564
  • Rimon A, Hunte C, Michel H and Padan E (2008) Epitope mapping of conformational monoclonal antibodies specific to NhaA Na+/H+ antiporter, structural and functional implications. J. Mol. Biol. 379, 471-481
  • Hunte C, Solmaz S, Palsdóttir H, Wenz T (2008) A structural perspective on mechanism and function of the cytochrome bc1 complex. Results Probl Cell Differ. 45, 53-78 (review)
  • Plewnia G, Schulze K, Hunte C, Tampé R, Koch J (2007) Modulation of the antigenic peptide transporter TAP by recombinant antibodies binding to the last five residues of TAP1. J. Mol. Biol. 369, 95-107
  • Screpanti, E and Hunte C (2007) Discontinuous membrane helices in transport proteins and their correlation with function. J. Struct. Biol. 159, 261-267 (review)
  • Lancaster CRD, Hunte C, Kelley III. J, Trumpower BL, Ditchfield RA (2007) comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex. J. Mol. Biol. 368, 197-208
  • Klingen AR, Palsdottir H, Hunte C, Ullmann M. (2007) Redox-linked protonation state changes in cytochrome bc1 identified by Poisson-Boltzmann Electrostatics Calculations. Biochim. Biophys. Acta 1767, 204-221
  • Wenz T, Covian R, Hellwig P, MacMillan F, Meunier B, Trumpower BL, Hunte C (2007) Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex III. J. Biol. Chem. 282, 3977-3988
  • Screpanti E, Padan E, Rimon A, Michel H, Hunte C (2006) Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformation. J. Mol. Biol. 362, 192-202
  • Wenz T, Hellwig P, MacMillan F, Meunier B, Hunte C (2006) Probing the role of E272 in quinol oxidation of mitochondrial complex III. Biochemistry 45, 9042-9052
  • Olkhova E, Hunte C, Screpanti E, Padan E, Michel H (2006) Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications. Proc. Natl. Acad. Sci. USA 103, 2629-2634
  • Hielscher R, Wenz T, Stolpe S, Hunte C, Friedrich T, Hellwig P (2006) Monitoring redox dependent contribution of lipids in FTIR difference spectra of complex I from E. coli. Biopolymers 82, 291-294


  • Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H (2005) Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature 435, 1197-1202
  • Hunte C (2005) Specific protein-lipid interactions in membrane proteins. Biochem. Soc. Trans. 33, 938-942 (review)
  • Palsdottir H, Hunte C (2004) Lipids in Membrane Protein Structures. Biochim. Biophys. Acta 1666, 2-18 (review)
  • Ritter M, Palsdottir H, Abe M, Mäntele W, Hunte C, Miyoshi H, Hellwig P(2004) Direct evidence for the interaction of stigmatellin with a protonated acidic group in the bc1 complex from Saccharomyces cerevisiae as monitored by FTIR difference spectroscopy and 13C specific labeling. Biochemistry 43, 8439-8446
  • Pfeiffer K, Gohil V, Stuart RA, Hunte C, Brandt U, Greenberg ML, Schägger H (2003) Cardiolipin stabilizes respiratory chain supercomplexes. J. Biol. Chem. 278, 52873-52880
  • Zickermann V, Bostina M, Hunte C, Ruiz T, Radermacher M, Brandt U (2003) Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase. J. Biol. Chem. 278, 29072-29078
  • Kessl JJ, Lange BB, Merbitz-Zahradnik T, Zwicker K, Hill P, Meunier B, Hunte C, Meshnik S, Trumpower BL (2003) Molecular basis for atovaquone binding to the cytochrome bc1 complex. J. Biol. Chem. 278, 31312-31318
  • Hunte C, Palsdottir H, Trumpower BL (2003) Protonmotive pathways and mechanisms in the cytochrome bc1 complex. FEBS Lettr. 545, 39-46 (review)
  • Venturi M, Hunte C (2003) Monoclonal antibodies for the structural analysis of the Na+/H+ antiporter NhaA from Escherichia coli. Biochim. Biophys. Acta 1610, 46-50 (review)
  • Palsdottir H, Lojero GC, Trumpower BL, Hunte C (2003) Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo inhibitor bound. J. Biol. Chem. 278, 31303-31311
  • Lange C, Hunte C (2002) Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c. Proc. Natl. Acad. Sci. USA  99, 2800-2805
  • Venturi M, Seifert C, Hunte C (2002) High level production of functional antibody Fab fragments in an oxidizing bacterial cytoplasm J. Mol. Biol. 315, 1 - 8
  • Hunte C, Solmaz S, Lange C (2002) Electron transfer between yeast cytochrome bc1 complex and cytochrome c: a structural analysis. Biochim. Biophys. Acta 1555, 21-28 (review)
  • Hunte C, Michel H (2002) Crystallisation of membrane proteins mediated by antibody fragments. Curr. Op. Struct. Biol. 12, 503-508 (review)
  • Lange C, Nett JH, Trumpower BL, Hunte C (2001) Specific roles of tightly bound phospholipids in the yeast cytochrome bc1 complex structure. EMBO J. 20, 6591-6600
  • Lee SY, Hunte C, Malaney S, Robinson BH (2001) The N-terminus of the Qcr7 Protein of the Cytochrome bc1 Complex in S. cerevisiae May Be Involved in Facilitating Stability of the Subcomplex with the Qcr8 Protein and Cytochrome b. Arch. Biochem. Biophys. 393, 215-221
  • Hunte C (2001) Insights from the structure of the yeast cytochrome bc1 complex. Crystallization of membrane proteins with antibody fragments. FEBS Lett. 504, 126-132 (review)
  • Nett JH, Hunte C, Trumpower BL (2000) Changes to the length of the flexible linker region of the Rieske protein impair the interaction of ubiquinol with the cytochrome bc1 complex. Eur. J. Biochem. 267, 5777-5782
  • Venturi M, Rimon A, Gerchman Y, Hunte C, Padan E, Michel H (2000) The monoclonal antibody 1F6 Identifies a pH-dependent Conformational Change in the hydrophilic NH2 Terminus of NhaA Na+/H+-antiporter of Escherichia coli. J. Biol. Chem. 275, 4734-4742
  • Hunte C, Köpke J, Lange C, Roßmanith T, Michel H (2000) Structure at 2.3 Å resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 8, 669-684
  • Padan E, Venturi M, Michel H, Hunte C (1998) Production and characterization of monoclonal antibodies directed against native epitopes of NhaA, the Na+/H+-antiporter of Escherichia coli. FEBS Lett. 441, 53-58
  • Schnabl H, Hunte C, Schulz M, Wolf D, Ghiena-Rahlenbeck C, Bramer M, Graab M, Janssen M, Kalweit H (1996) Effects of fast clinostat treatment and microgravity on Vicia faba L. mesophyll cell protoplast ubiquitin pools and actin isoforms. Microgravity Sci. Tec. 9, 275-280
  • Bramer M, Hunte C, Schulz M, Schnabl H (1996) Microsomal membrane proteins and vanadate-sensitive ATPase of Vicia faba root tips after clinostat treatment. Plant Physiol. Biochem. 34, 465-472
  • Janssen M, Hunte C, Schulz M, Schnabl H (1996) Tissue specification and intracellular distribution of actin isoforms in Vicia faba L.. Protoplasma 191, 158-163
  • Janssen M, Hunte C, Leineweber K, Knop M, Cramer H, Traub O, Schulz M (1994) Tissue and cell specific distribution of connexin 32- and connexin 26- related proteins from Vicia faba L.. Bot. Acta 107, 468-472
  • Hunte C, Janssen M, Schulz M, Traub O, Schnabl H (1993) Age dependent modifications and further localization of the cx-like protein from Vicia faba L..  Bot. Acta 106, 207-212
  • Hunte C, Schulz M, Schnabl H (1993) Influence of clinostat rotation on plant proteins: 2. Effects on membrane bound enyzme activities and ubiquitin-protein-conjugates in leaves of Vicia faba L.. J. Plant Physiol. 142, 31-36.
  • Schulz M, Klockenbring T, Hunte C, Schnabl (1993) Involvement of ubiquitin in phosphoenolpyruvate degradation. Bot. Acta 106, 143-145
  • Hunte C, Schnabl H, Traub O, Willecke K, Schulz M (1992) Immunological evidence for connexin-like proteins in the plasma membrane of Vicia faba L.. Bot. Acta 105, 104-110
  • Schulz M, Hunte C, Schnabl H (1992) Multiple forms of phosphoenolpyruvate carboxylase in mesophyll, epidermal and guard cells of Vicia faba L.. Physiol. Plantarum 86, 315-321.