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PhD student / Doktorand/in (E13, 65%)


Mitochondrial architecture and function


The membrane architecture of mitochondria directly influences the organelle's functionality and efficiency, and its disruption is associated with human disease. The characteristic cristae membranes are topologically and functionally specialized for optimal respiration. Cristae morphology is governed by the balanced actions of several protein complexes of the inner membrane. We offer a PhD position to investigate the functions of the widely conserved MICOS complex (mitochondrial contact site and cristae organizing system). MICOS is required for the stability of crista junctions that connect the cristae membranes to the smooth areas of the inner membrane. It also plays important roles in other aspects of mitochondrial physiology, including protein and phospholipid biogenesis, respiration, mitochondrial dynamics, and maintenance of mitochondrial DNA. We employ a wide range of biochemical methods for the study of native membrane protein complexes, as well as techniques from molecular biology and cell biology such as fluorescence microscopy and mitochondrial physiology measurements.


We are looking to recruit a highly motivated student with a strong background in biology / biochemistry and keen scientific interests. The position is available at the earliest possible date, we offer a salary according to E13 (65%). The Institute for Biochemistry and Molecular Biology at the University of Freiburg provides an excellent and stimulating research environment.

The University of Freiburg seeks to increase the number of female employees and therefore encourages qualified women to apply for the position. Applicants with disabilities (Schwerbehinderte) will be given preferential consideration in case of equal qualification.




Dr. Heike Rampelt

Institute for Biochemistry and Molecular Biology, ZBMZ

Stefan-Meier-Str. 17

79104 Freiburg