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Publications

2016

  • Stiller SB, Höpker J, Oeljeklaus S, Schütze C, Schrempp SG, Vent-Schmidt J, Horvath, SE, Frazier AE, Gebert N, van der Laan M, Bohnert M, Warscheid B, Pfanner N, and Wiedemann N: Mitochondrial OXA translocase plays a major role in biogenesis of inner-membrane proteins. Cell Metab, 2016; 23 : 901-908.
  • Ellenrieder L, Opalinski L, Becker L, Krüger V, Mirus O, Straub SP, Ebell K, Flinner N, Stiller SB, Guiard B, Meisinger C, Wiedemann N, Schleiff E, Wagner R, Pfanner N, Becker T: Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10. Nat Commun, 2016; 7 : 13021.
  • Straub SP, Stiller SB, Wiedemann N, Pfanner N: Dynamic organization of the mitochondrial protein import machinery. Biol Chem, 2016; epub June 11, 2016, doi: 10.1515/hsz-2016-0145.
  • Yofe I, Weill U, Meurer M, Chuartzman S, Zalckvar E, Goldman O, Ben-Dor S, Schütze C, Wiedemann N, Knop M, Khmelinskii A, Schuldiner M: One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods, 2016; 13 : 371-378.

 

2015

  • Wenz L-S, Ellenrieder L, Qiu J, Bohnert M, Zufall N, van der Laan M, Pfanner N, Wiedemann N, Becker T: Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis. J Cell Biol, 2015; 210 : 1047–1054.
  • Shiota T, Imai K, Qiu J, Hewitt VL, Tan K, Shen H-H, Sakiyama N, Fukasawa Y, Hayat S, Kamiya M, Elofsson A, Tomii K, Horton P, Wiedemann N, Pfanner N, Lithgow T, Endo T: Molecular architecture of the active mitochondrial protein gate. Science, 2015; 349 : 1544–1548.
  • Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C: The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. J Cell Biol, 2015; 210 : 951–960.
  • Elbaz-Alon Y, Eisenberg-Bord M, Shinder V, Stiller SB, Shimoni E, Wiedemann N, Geiger T, Schuldiner M: Lam6 Regulates the Extent of Contacts between Organelles. Cell Rep, 2015; 12 : 7–14.
  • Bragoszewski P, Wasilewski M, Sakowska P, Gornicka A, Böttinger L, Qiu J, Wiedemann N, Chacinska A: Retro-translocation of mitochondrial intermembrane space proteins. Proc Natl Acad Sci USA, 2015; 112 : 7713–7718.
  • Wenz L-S, Opaliński Ł, Wiedemann N, Becker T: Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta, 2015; 1853 : 1119–1129.
  • Höhr AI, Straub SP, Warscheid B, Becker T, Wiedemann N: Assembly of β-barrel proteins in the mitochondrial outer membrane. Biochim Biophys Acta, 2015; 1853 (1) : 74-88.
 

2014

  • Mossmann D, Vögtle FN, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N, Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C: Amyloid-beta Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation. Cell Metabolism, 2014; 20 (4) : 1-8
  • Wenz L.-S, Opalinski L, Schuler M-H, Ellenrieder L, Ieva, R, Böttinger, L, Qiu J, van der Laan, M, Wiedemann N, Guiard B, Pfanner N, Becker  T. The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. EMBO Rep, 2014; 15 (6) : 678-85.
  • Wenz L-S, Qiu J, Becker T,  Wiedemann N: Biogenesis and folding of β-barrel membrane proteins. Cell Cycle, 2014; 13(2) : 169–170.

 

2013

  • Böttinger L, Guiard B, Oeljeklaus S, Kulawiak B, Zufall N, Wiedemann N, Warscheid B, van der Laan M, Becker T: A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Mol Biol Cell, 2013; 24 (17) : 2609-2619.
  • Kulawiak B, Hopker J, Gebert M, Guiard B, Wiedemann N, Gebert N: The mitochondrial protein import machinery has multiple connections to the respiratory chain Biochim Biophys Acta. , 2013; 1827 (5) : 612-626.
  • Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T: Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell, 2013; 154 (3) : 596-608.
  • Wiedemann N, Stiller SB, Pfanner N: Activation and degradation of mitofusins: two pathways regulate mitochondrial fusion by reversible ubiquitylation. Mol Cell, 2013; 49 (3) : 423-425.
 

2012

  • Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Muller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M: Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol Biol Cell, 2012; 23 (20) : 3948-3956.
  • Horvath SE, Böttinger L, Vögtle FN, Wiedemann N, Meisinger C, Becker T, Daum G: Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. J Biol Chem, 2012; 287 (44) : 36744-36755.
  • Reinhold R, Krüger V, Meinecke M, Schulz C, Schmidt B, Grunau SD, Guiard B, Wiedemann N, van der Laan M, Wagner R, Rehling P, Dudek J: The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol Cell Biol, 2012; 32 (24) : 5009-5021.
  • Van der Laan M, Bohnert M, Wiedemann N, Pfanner N: Role of MINOS in mitochondrial membrane architecture and biogenesis. Trends Cell Biol, 2012; 22 (4) : 185-192.
  • Zerbes RM, Bohnert M, Stroud DA, von der Malsburg K, Kram A, Oeljeklaus S, Warscheid B, Becker T, Wiedemann N, Veenhuis M, van der Klei IJ, Pfanner N, van der Laan M: Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J Mol Biol, 2012; 422 (2) : 183-191.
 

2011

  • Becker T, Wenz LS, Thornton N, Stroud D, Meisinger C, Wiedemann N, Pfanner N: Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane. J Mol Biol, 2011; 405 (1) : 113-124.
  • Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N: Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell, 2011; 44 (5) : 811-818.
  • Qian X, Gebert M, Hopker J, Yan M, Li J, Wiedemann N, van der Laan M, Pfanner N, Sha B: Structural basis for the function of Tim50 in the mitochondrial presequence translocase. J Mol Biol, 2011; 411 (3) : 513-519.
  • Stroud DA, Becker T, Qiu J, Stojanovski D, Pfannschmidt S, Wirth C, Hunte C, Guiard B, Meisinger C, Pfanner N, Wiedemann N: Biogenesis of mitochondrial beta-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol Biol Cell, 2011; 22 (16) : 2823-2833
  • Stroud DA, Oeljeklaus S, Wiese S, Bohnert M, Lewandrowski U, Sickmann A, Guiard B, van der Laan M, Warscheid B, Wiedemann N: Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol, 2011; 413 (4) : 743-750:
  • Gebert N, Ryan MT, Pfanner N, Wiedemann N, Stojanovski D: Mitochondrial protein import machineries and lipids: a functional connection Biochim Biophys Acta, 2011; 1808 (3) : 1002-1011:
 

2010

  • Becker T, Guiard B, Thornton N, Zufall N, Stroud DA, Wiedemann N, Pfanner N: Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex. Mol Biol Cell, 2010; 21 (18) : 3106-3113.
  • Chacinska A, van der Laan M, Mehnert CS, Guiard B, Mick DU, Hutu DP, Truscott KN, Wiedemann N, Meisinger C, Pfanner N, Rehling P: Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol, 2010; 30 (1) : 307-318.
  • Stroud DA, Meisinger C, Pfanner N, Wiedemann N: Biochemistry. Assembling the outer membrane. Science, 2010; 328 (5980) : 831-832.
 

2009

  • Gebert N, Joshi AS, Kutik S, Becker T, McKenzie M, Guan XL, Mooga VP, Stroud DA, Kulkarni G, Wenk MR, Rehling P, Meisinger C, Ryan MT, Wiedemann N, Greenberg ML, Pfanner N: Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol, 2009; 19 (24) : 2133-2139.
  • Wiedemann N, Meisinger C, Pfanner N: Cell biology. Connecting organelles. Science, 2009; 325 (5939). 403-404.
  • Kutik S, Stroud DA, Wiedemann N, Pfanner N: Evolution of mitochondrial protein biogenesis. Biochim Biophys Acta, 2009; 1790 (6) : 409-415.
  • Wiedemann N, van der Laan M, Pfanner N: SnapShot: import and sorting of mitochondrial proteins. Cell, 2009; 138 (4) : 808-808.e1.
 

2008

  • Becker T, Pfannschmidt S, Guiard B, Stojanovski D, Milenkovic D, Kutik S, Pfanner N, Meisinger C, Wiedemann N: Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem, 2008; 283 (1) : 120-127.
  • Gebert N, Chacinska A, Wagner K, Guiard B, Koehler CM, Rehling P, Pfanner N, Wiedemann N: Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep, 2008; 9 (6) : 548-554.
  • Kutik S, Rissler M, Guan XL, Guiard B, Shui G, Gebert N, Heacock PN, Rehling P, Dowhan W, Wenk MR, Pfanner N, Wiedemann N: The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol, 2008; 183 (7) : 1213-1221.
  • Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N, Wiedemann N: Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell, 2008; 132 (6) : 1011-1024.
  • Wagner K, Gebert N, Guiard B, Brandner K, Truscott KN, Wiedemann N, Pfanner N, Rehling P: The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Mol Cell Biol, 2008; 28 (13) : 4251-4260.
  • Kutik S, Stojanovski D, Becker T, Stroud DA, Becker L, Meinecke M, Krüger V, Prinz C, Guiard B, Wagner R, Meisinger C, Pfanner N, Wiedemann N: Response: The Mitochondrial beta-Signal and Protein Sorting. Cell, 2008; 135 (7) : 1159-1160.

 

2007

  • Kutik S, Guiard B, Meyer HE, Wiedemann N, Pfanner N: Cooperation of translocase complexes in mitochondrial protein import. J Cell Biol, 2007; 179 (4) : 585-591.
  • Meisinger C, Pfannschmidt S, Rissler M, Milenkovic D, Becker T, Stojanovski D, Youngman MJ, Jensen RE, Chacinska A, Guiard B, Pfanner N, Wiedemann N: The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J, 2007; 26 (9) : 2229-2239.
  • Wiedemann N, van der Laan M, Hutu DP, Rehling P, Pfanner N: Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain. J Cell Biol, 2007; 179 : 1115-1122.
  • Stojanovski D, Pfannner N, Wiedemann N: Import of proteins into mitochondria. Method Cell Biol, 2007; 80 : 783-806.

 

2006

  • Meisinger C, Wiedemann N, Rissler M, Strub A, Milenkovic D, Schönfisch B, Muller H, Kozjak V, Pfanner N: Mitochondrial protein sorting: differentiation of beta-barrel assembly by J Biol Chem, 2006; 281 (32) : 22819-22826.
  • Wiedemann N, Pfanner N, Chacinska A: Chaperoning through the Mitochondrial Intermembrane Space. Mol Cell, 2006; 21 (2) : 145-148.
  • Wiedemann N, Pfanner N, Rehling P: Import of precursor proteins into isolated yeast mitochondria. Methods Mol Biol, 2006; 313 : 373-384.
  • Wiedemann N, Urzica E, Guiard B, Muller H, Lohaus C, Meyer HE, Ryan MT, Meisinger C, Muhlenhoff U, Lill R, Pfanner N: Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J, 2006; 25 (1) : 184-195.
  • van der Laan M, Wiedemann N, Mick DU, Guiard B, Rehling P, Pfanner N: A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria. Curr Biol, 2006; 16 (22) : 2271-2276.

 

2005

  • Rissler M, Wiedemann N, Pfannschmidt S, Gabriel K, Guiard B, Pfanner N, Chacinska A: The Essential Mitochondrial Protein Erv1 Cooperates with Mia40 in Biogenesis of Intermembrane Space Proteins. J Mol Biol, 2005; 353 : 485-492.
  • Sanjuan Szklarz LK, Guiard B, Rissler M, Wiedemann N, Kozjak V, van der Laan M, Lohaus C, Marcus K, Meyer HE, Chacinska A, Pfanner N, Meisinger C: Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J Mol Biol, 2005; 351 (1) : 206-218.

 

2004

  • Chacinska A, Pfannschmidt S, Wiedemann N, Kozjak V, Sanjuan Szklarz LK, Schulze-Specking A, Truscott KN, Guiard B, Meisinger C, Pfanner N: Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. Embo J, 2004; 23 (19) : 3735-3746.
  • Meisinger C, Rissler M, Chacinska A, Szklarz LK, Milenkovic D, Kozjak V, Schönfisch B, Lohaus C, Meyer HE, Yaffe MP, Guiard B, Wiedemann N, Pfanner N: The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell, 2004; 7 (1) : 61-71.
  • Milenkovic D, Kozjak V, Wiedemann N, Lohaus C, Meyer HE, Guiard B, Pfanner N, Meisinger C: Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J Biol Chem, 2004; 279 (21) : 22781-22785.
  • Pfanner N, Wiedemann N, Meisinger C: Cell biology. Double membrane fusion. Science, 2004; 305 (5691) : 1723-1724.
  • Pfanner N, Wiedemann N, Meisinger C, Lithgow T: Assembling the mitochondrial outer membrane. Nat Struct Mol Biol, 2004; 11 (11) : 1044-1048.
  • Wiedemann N, Frazier AE, Pfanner N: The protein import machinery of mitochondria. J Biol Chem, 2004; 279 (15) : 14473-14476.
  • Wiedemann N, Truscott KN, Pfannschmidt S, Guiard B, Meisinger C, Pfanner N: Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J Biol Chem, 2004; 279 (18) : 18188-18194.
  • Wiedemann N, Frazier AE, Pfanner N: The protein import machinery of mitochondria. J Biol Chem, 2004; 279 (15) : 14473-14476.

 

2003

  • Kozjak V, Wiedemann N, Milenkovic D, Lohaus C, Meyer HE, Guiard B, Meisinger C, Pfanner N: An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem, 2003; 278 (49) : 48520-48523.
  • Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N, Meisinger C: Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature, 2003; 424 (6948) : 565-571.
  • Wiedemann N, Kozjak V, Prinz T, Ryan MT, Meisinger C, Pfanner N, Truscott KN: Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery. J Mol Biol, 2003; 327 (2) : 465-474.

   

 2002

  • Geissler A, Chacinska A, Truscott KN, Wiedemann N, Brandner K, Sickmann A, Meyer HE, Meisinger C, Pfanner N, Rehling P: The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell, 2002; 111 (4) : 507-518.
  • Pfanner N, Wiedemann N: Mitochondrial protein import: two membranes, three translocases. Curr Opin Cell Biol, 2002; 14 (4) : 400-411.
  • Truscott KN, Wiedemann N, Rehling P, Müller H, Meisinger C, Pfanner N, Guiard B: Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol Cell Biol, 2002; 22 (22) : 7780-7789.

 

2001

  • Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N, Ryan MT: Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol, 2001; 8 (4) : 361-370.
  • Rehling P, Wiedemann N, Pfanner N, Truscott KN: The mitochondrial import machinery for preproteins. Crit Rev Biochem Mol, 2001; 36 (3) : 291-336.
  • Wiedemann N, Pfanner N, Ryan MT: The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J, 2001; 20 (5) : 951-960.

 

 

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