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Publications

 

2017

 
Di Bartolomeo, F., Doan, K.N., Athenstaedt, K.#, Becker, T.# and Daum, G.# (2017) Involvement of a putative substrate binding site in the biogenesis and assembly of phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae. Biochim Biophys Acta. 1862, 716-725 (#corresponding author)

Ellenrieder, L., Rampelt, H. and Becker, T. (2017) Connection of protein transport and organelle contact sites in mitochondria. J. Mol. Biol. 429, 2148-2160.

Mårtensson, C.U., Doan, K.N. and Becker, T. (2017) Effects of lipids on mitochondrial functions. Biochim Biophys Acta. 182, 102-113.
 

2016

 
Ellenrieder, L., Opalinski, L., Becker, L., Krüger, V., Mirus, O., Straub, S.P., Ebell, K., Flinner, N., Stiller, S.B., Guiard, B., Meisinger, C., Wiedemann, N., Schleiff, E., Wagner, R., Pfanner, N., and Becker, T. (2016) Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10. Nat. Commun. 7:13021.

Chatterjee, A., Seyfferth, J., Lucci, J., Gilsbach, R., Preissl, S., Böttinger, L., Mårtensson, C.U., Panhale, A., Stehle, T., Kretz, O., Sahyoun, A.H., Avilov, S., Eimer, S., Hein, L., Pfanner, N., Becker, T. and Akhtar, A. (2016) MOF acetyl transferase regulates transcription and respiration in mitochondria. Cell 167, 722-738.

Schuler, M.H., Di Bartolomeo, F., Mårtensson, C.U., Daum, G. and Becker, T. (2016) Phosphatidylcholine affects inner membrane protein translocases of mitochondria. J. Biol. Chem. 291, 18718-18729.

Bionda, T., Gross, L., Becker, T., Papasotiriou, D.G., Leisegang, M.S., Karas, M. and Schleiff, E. (2016) Eukaryotic Hsp70 chaperones in the intermembrane space of chloroplasts. Planta 243, 733-747.

Müller, C.S., Bildl, W., Haupt, A., Ellenrieder, L., Becker, T., Hunte, C., Fakler, B. and Schulte, U. (2016) Cryo-slicing BN-MS – a novel technology for high-resolution complexome profiling. Mol. Cell. Proteomics 15, 669-681.

Böttinger, L., Ellenrieder, L. and Becker, T. (2016) How lipids modulate mitochondrial protein import. J. Bioenerg. Biomembr. 48, 125-135.

 

2015

 

Wenz, L.S., Ellenrieder, L., Qiu, J., Bohnert, M., Zufall, N., van der Laan, M., Pfanner, N., Wiedemann, N. and Becker, T. (2015) Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis. J. Cell. Biol. 210, 1047-1054.

Schuler, M.H., Di Bartolomeo, F., Böttinger, L., Horvath, S.E., Wenz, L.S., Daum, G. and Becker, T. (2015) Phosphatidylcholine affects the role of the sorting and assembly machinery in the biogenesis of mitochondrial β-barrel proteins. J. Biol. Chem. 290, 26523-26532.

Böttinger, L., Oeljeklaus, S., Guiard, B., Rospert, S., Warscheid, B. and Becker, T. (2015) The mitochondrial heat shock protein 70 (Hsp70) and Hsp10 cooperate in the formation of Hsp60 complexes. J. Biol. Chem. 290, 11611-11622.

Ellenrieder, L., Martensson, C.U. and Becker, T. (2015) Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Biol. Chem. 396, 1199-1213.

Wenz, L.S., Opalinski, L., Wiedemann, N. and Becker, T. (2015) Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 1853, 1119-1129.

Höhr, A.I.C., Straub, S.P., Warscheid, B., Becker, T. and Wiedemann, N. (2015) Assembly of β-barrel protein in the mitochondrial outer membrane. Biochim Biophys Acta. 1853, 74-88.

 

2014

 
Ieva, R., Schrempp, S.G., Opalinski, L., Wollweber, F., Höß, P., Heißwolf, A., Gebert, M., Zhang, Y., Guiard, B., Rospert, S., Becker, T., Chacinska, A., Pfanner, N. and van der Laan, M. (2014) Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol. Cell 56, 641-652.
 
Wenz, L.S., Opalinski, L., Schuler, M.H., Ellenrieder, L., Ieva, R., Böttinger, L., Qiu, J., van der Laan, M., Wiedemann, N., Guiard, B., Pfanner, N. and Becker, T. (2014) The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. EMBO Rep. 15, 678-685.
 
Opalinski, L., Becker, T. and Pfanner, N. (2014) Clearing tail-anchored proteins from mitochondria. Proc. Natl. Acad. Sci. USA 111, 7888-7889.
 
Wenz, L.S., Qiu, J., Becker, T. and Wiedemann, N. (2014) Biogenesis and folding of β-barrel membrane proteins. Cell Cycle 13, 169-170.
 
 

2013

 
Böttinger, L., Guiard, B., Oeljeklaus, S., Kulawiak, B., Zufall, N., Wiedemann, N., Warscheid, B., van der Laan, M. and Becker, T. (2013) A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Mol. Biol. Cell. 24, 2609-2619.
 
Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S., Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N. and Becker, T. (2013) Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154, 596-608.
 
Becker, T.*, Horvath, S.E.*, Böttinger, L.*, Gebert, N., Daum, G. and Pfanner, N. (2013) Role of phosphatidylethanolamine in the biogenesis of mitochondrial outer membrane proteins. J. Biol. Chem. 288, 16451-16459. (*equal contribution)
 
Flinner, N., Ellenrieder, L., Stiller, S.B., Becker, T., Schleiff, E. and Mirus, O. (2013) Mdm10 is an ancient eukaryotic porin co-occuring with the ERMES complex. Biochim. Biophys. Acta. 1833, 3314-3325.
 
 

2012

 
Horvath, S.E., Böttinger, L., Vögtle, F.N., Wiedemann, N., Meisinger, C., Becker, T.# and Daum, G.# (2012) Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. J. Biol. Chem. 287, 36744-36755. (#co-corresponding)
 
Böttinger, L., Horvath, S.E., Kleinschroth, T., Hunte, C., Daum, G., Pfanner, N. and Becker, T. (2012) Phosphatidylethanolamine and cardiolipin differently affect the stability of mitochondrial respiratory chain supercomplexes. J. Mol. Biol. 423, 677-686.
 
Bohnert, M., Wenz, L.S., Zerbes, R.M., Horvath, S.E., Stroud, D.A., von der Malsburg, K., Müller, J.M., Oeljeklaus, S., Perschill, I., Warscheid, B., Chacinska, A., Veenhuis, M., van der Klei, I.J., Daum, G., Wiedemann, N., Becker, T., Pfanner, N. and van der Laan, M. (2012) Role of MINOS in protein biogenesis of the mitochondrial outer membrane. Mol. Biol. Cell 23, 3948-3956.
 
Zerbes, R.M., Bohnert, M., Stroud, D.A., von der Malsburg, K., Kram, A., Oeljeklaus, S., Warscheid, B., Becker, T., Wiedemann, N., Veenhuis, M., van der Klei, I.J., Pfanner, N. and van der Laan, M. (2012) Role of MINOS in mitochondrial membrane architecture: Cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J. Mol. Biol. 422, 183-191.
 
Elkehal, R., Becker, T., Sommer, M.S., Königer, M. and Schleiff, E. (2012) Specific lipids influence the import capacity of the chloroplasts outer envelope precursor protein translocon. Biochim. Biophys. Acta, 1823, 1033-1040.
 
Wenz, L.S., Pfanner, N. and Becker, T. (2012) Mitochondriale Systeme für den Import von Proteinen. Biospektrum 18, 706-709.
 
Böttinger, L. and Becker, T. (2012) Protein quality control in the intermembrane space of mitochondria. J. Mol. Biol. 424, 225-226.
 
Becker, T., Böttinger, L. and Pfanner, N. (2012) Mitochondrial protein import: from transport pathways to an integrated network. Trends Biochem. Sci., 37, 85-91.
 
 

2011

 
von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J-C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner, N., Chacinska, A. and van der Laan, M. (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev. Cell, 21, 694-707.
 
Becker, T., Wenz, L.S., Krüger, V., Lehmann, W., Müller, J.M., Goroncy, L., Zufall, N., Lithgow, T., Guiard, B., Chacinska, A., Wagner, R., Meisinger, C. and Pfanner, N. (2011) The mitochondrial import protein Mim1 promotes biogenesis of multi-spanning outer membrane proteins. J. Cell. Biol. 194, 387-395.
 
Stroud, D.A., Becker, T., Qiu, J., Stojanovski, D., Pfannschmidt, S., Wirth, C., Hunte, C., Guiard, B., Meisinger, C., Pfanner, N. and Wiedemann, N. (2011) Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol. Biol. Cell. 22, 2823-2833.
 
Becker, T., Wenz, L.S., Thornton, N., Stroud, D.A., Meisinger, C., Wiedemann, N. and Pfanner, N. (2011) Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane. J. Mol. Biol. 405, 113-124.
 
Schleiff, E., Maier, U.G. and Becker, T. (2011) Omp85 in eukaryotic systems: one protein family with distinct functions. Biol. Chem. 392, 21-27.
 
Schleiff, E. and Becker, T. (2011) Common ground for protein translocation: access control for mitochondria and chloroplasts. Nat. Rev. Mol. Cell Biol. 12, 48-59.
 
 

2010

 
Becker, T., Guiard, B., Thornton, N., Zufall, N., Stroud, D.A., Wiedemann, N. and Pfanner, N. (2010) Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction with the SAM complex. Mol. Biol. Cell 14, 3106-3113.
 
Thornton, N., Stroud, D.A., Milenkovic, D., Guiard, B., Pfanner, N. and Becker, T. (2010) Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of a-helical outer membrane proteins J. Mol. Biol. 396, 540-549.
 
Kamenisch, Y., Fousteri, M., Knoch, J., von Thaler, A-K., Fehrenbacher, B., Kato, H., Becker, T., Dolle M., Kuiper, R., Majora, M., Schaller, M., van der Horst, G., van Steeg, H., Röcken, M., Rapaport, D., Krutmann, J., Mullenders, L.H. and Berneburg, M. (2010) Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J. Exp. Med. 207, 379-390.
 
 

2009

 
Gebert, N., Joshi, A.S., Kutik, S., Becker, T., McKenzie, M., Guan, X.L., Mooga, V.P., Stroud, D.S., Kulharni, G., Wenk, M.R., Rehling, P., Meisinger, C., Ryan, M.T., Wiedemann, N., Greenberg, M.L. and Pfanner, N. (2009) Mitochondrial Cardiolipin involved in outer-membrane protein biogenesis: Implications for the Barth Syndrome. Curr. Biol. 19, 2133-2139.
 
Becker, T., Gebert, M., Pfanner, N. and van der Laan, M. (2009) Biogenesis of mitochondrial membrane proteins. Curr. Opin. Cell Biol. 21, 484-493.
 
 

2008

 
Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N. and Wiedemann, N. (2008) Dissecting membrane insertion of mitochondrial β-barrel proteins. Cell, 132, 1011-1024.
 
Kutik, S., Stojanovski, D., Becker, T., Stroud, D.A., Becker, L., Meineke, M., Krüger, V., Prinz, C., Guiard, B., Wagner, R., Meisinger, C., Pfanner, N. and Wiedemann, N. (2008) The mitochondrial β-signal and protein sorting. Cell 135, 1159-1160. (comment to Kutik et al., 2008, Cell 132, 1011-1024)
 
Becker, T., Pfannschmidt, S., Guiard, B., Stojanovski, D., Milenkovic, D., Kutik, S., Pfanner, Meisinger, C. and Wiedemann, N. (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J. Biol. Chem., 283, 120-127.
 
Becker, T., Vögtle, F.N., Stojanovski, D. and Meisinger, C. (2008) Sorting and assembly of mitochondrial outer membrane proteins. Biochim. Biophys. Acta. 1777, 447-563.
 
 

2007

 
Meisinger, C., Pfannschmidt, S., Rissler, M., Milenkovic, D., Becker, T., Stojanovski, D., Youngman, M.J., Jensen, R.E., Chacinska, A., Giuard, B., Pfanner, N. and Wiedemann, N. (2007) The morphology proteins Mdm12/Mmm1 function in the major β-barrel assembly pathway of mitochondria. EMBO J., 26, 2229-2239.
 
Kempa S., Rozhon, W., Samaj, J., Erban, A., Baluska, F., Becker T., Haselmayer, J., Schleiff, E., Kopka, J., Hirt, H. and Jonak, C. (2007) A plastid-localised glycogen synthase kinase 3 modulates stress tolerance and carbohydrate metabolism. Plant J., 47, 1076-1090.
 
Qbadou, S., Becker, T., Bionda, T., Reger, K., Ruprecht, M., Soll, J. and Schleiff, E. (2007) Toc64 – A Preprotein-receptor at the outer membrane with bipartide function. J. Mol. Biol., 367, 1330-1346. 
 

2006

 
Qbadou, S. *, Becker, T*., Mirus, O., Sohrt, K., Tews, I., Soll, J. and Schleiff, E. (2006) The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64. EMBO J., 25, 1836-1847. (*equal contribution)
 

2005

 
Hemmler, R., Becker T., Schleiff, E., Bölter, B., Stahl, T., Soll, J., Götze, T.A., Braams, S. and Wagner, R. (2005) Molecular properties of Oep21 an ATP regulated anion selective solute channel from the chloroplasts outer membrane. J. Biol. Chem. 281, 12020-12029.
 
Bonardi, V., Pesaresi, P., Becker, T., Schleiff, E., Wagner, R., Pfannschmidt, T., Jahns, P. and Leister, D. (2005) PSII core phosphorylation and photosynthetic acclimation require two different protein kinases in Arabidopsis. Nature, 437, 1179-1182.
 
Ertel, F., Mirus, O., Bredemeyer, R., Moslavac, S., Becker, T. and Schleiff, E. (2005) The evolutionary related β-barrel polypeptide transporters from P. sativum and Anabaena contain two distinct functional domains. J. Biol. Chem., 280, 28281-28289.
 
Becker T., Qbadou S., Jelic, M. and Schleiff E. (2005) Let´s talk   about…chloroplast import. Plant Biol. 7, 1-14.
 
Becker T., Soll, J., and Schleiff E. (2005) Chaperone systems in chloroplasts. In Handbook of protein folding. Edited by Kiefhaber, T. and Buchner J., 1019-1064.
 

2004

 
Becker, T.*, Jelic, M.*, Vojta. A., Radunz, A., Soll. J. and Schleiff, E. (2004) Preprotein recognition by the Toc complex. EMBO J., 23, 520-530. (*equal contribution)
 
Vojta, A., Alavi, M., Becker, T., Hörmann, F., Küchler, M., Soll, J., Thomson, R. and Schleiff, E. (2004) The protein translocon of the plastid envelopes. J. Biol. Chem. 279, 21401-21405.
 
Becker, T., Hritz, J., Vogel, M., Caliebe, A., Bukau, B., Soll, J. and Schleiff E. (2004) Toc12, a novel subunit of the intermembrane space preprotein translocon of chloroplasts. Mol. Biol. Cell, 15, 5130-5144.
 

2003

 
Schleiff, E., Eichacker, L.A., Eckart, K., Becker, T., Mirus, O., Stahl, T. and Soll, J. (2003) Prediction of the plant β-barrel proteome: a case study of the chloroplast outer envelope. Protein Sci. 12, 748-759.

 

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